Skip to main content
SpringerLink
Log in

The Itch to degrade ROR-γt

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

The E3 ubiquitin ligase Itch limits interleukin 17A (IL-17A)-mediated intestinal inflammation by targeting the transcription factor ROR-γt for proteasomal degradation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Itch limits the production of IL-17A by TH17 cells, γδ T cells and group 3 innate lymphoid cells by targeting ROR-γt for proteasomal degradation.

Marina Corral Spence/Nature Publishing Group

References

  1. Kathania, M. et al. Nat. Immunol. 17, 997–1004 (2016).

    Article  CAS  PubMed  Google Scholar 

  2. Park, Y., Jin, H.-S., Aki, D., Lee, J. & Liu, Y.-C. Adv. Immunol. 124, 17–66 (2014).

    Article  PubMed  Google Scholar 

  3. Kulathu, Y. & Komander, D. Nat. Rev. Mol. Cell Biol. 13, 508–523 (2012).

    Article  CAS  PubMed  Google Scholar 

  4. Venuprasad, K., Zeng, M., Baughan, S.L. & Massoumi, R. Immunol. Cell Biol. 93, 452–460 (2015).

    Article  CAS  PubMed  Google Scholar 

  5. Aki, D., Zhang, W. & Liu, Y.-C. Immunol. Rev. 266, 6–26 (2015).

    Article  CAS  PubMed  Google Scholar 

  6. Lee, J.S. et al. Immunity 43, 727–738 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. West, N.R., McCuaig, S., Franchini, F. & Powrie, F. Nat. Rev. Immunol. 15, 615–629 (2015).

    Article  CAS  PubMed  Google Scholar 

  8. Rutz, S. et al. Nature 518, 417–421 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Wang, X. et al. J. Biol. Chem. 290, 29086–29094 (9 October 2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Yang, J. et al. J. Immunol. 194, 4094–4097 (2015).

    Article  CAS  PubMed  Google Scholar 

  11. Han, L. et al. J. Biol. Chem. 289, 25546–25555 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Layman, A.A.K. & Oliver, P.M. J. Immunol. 196, 3975–3982 (2016).

    Article  CAS  PubMed  Google Scholar 

  13. Huang, X. & Dixit, V.M. Cell Res. 26, 484–498 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sascha Rutz is in the Department of Cancer Immunology, Genentech, South San Francisco, California, USA.,

    Sascha Rutz

  2. Wenjun Ouyang is in the Department of Inflammation and Oncology, Amgen, South San Francisco, California, USA.,

    Wenjun Ouyang

Authors
  1. Sascha Rutz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wenjun Ouyang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Sascha Rutz or Wenjun Ouyang.

Ethics declarations

Competing interests

S.R. is an employee of Genentech, and W.O. is an employee of Amgen.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rutz, S., Ouyang, W. The Itch to degrade ROR-γt. Nat Immunol 17, 898–900 (2016). https://doi.org/10.1038/ni.3516

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3516

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation