Skip to main content

Advertisement

Log in

Vive la peptide différence!

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

The thymic development of CD8+ T cells requires the presentation of different sets of peptides on major histocompatibility complex class I for positive selection and negative selection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Models of thymic selection: affinity versus peptide switching.

References

  1. Kincaid, E.Z., Murata, S., Tanaka, K. & Rock, K.L. Nat. Immunol. 17, 938–945 (2016).

    Article  CAS  Google Scholar 

  2. Murata, S. et al. Science 316, 1349–1353 (2007).

    Article  CAS  Google Scholar 

  3. Nitta, T. et al. Immunity 32, 29–40 (2010).

    Article  CAS  Google Scholar 

  4. Xing, Y., Jameson, S.C. & Hogquist, K.A. Proc. Natl. Acad. Sci. USA 110, 6979–6984 (2013).

    Article  CAS  Google Scholar 

  5. Sasaki, K. et al. Nat. Commun. 6, 7484 (2015).

    Article  CAS  Google Scholar 

  6. Takada, K. et al. Nat. Immunol. 16, 1069–1076 (2015).

    Article  CAS  Google Scholar 

  7. Azzam, H.S. et al. J. Exp. Med. 188, 2301–2311 (1998).

    Article  CAS  Google Scholar 

  8. Marrack, P. & Kappler, J. Science 238, 1073–1079 (1987).

    Article  CAS  Google Scholar 

  9. Klein, L., Hinterberger, M., Wirnsberger, G. & Kyewski, B. Nat. Rev. Immunol. 9, 833–844 (2009).

    Article  CAS  Google Scholar 

  10. Fu, G. et al. Trends Immunol. 35, 311–318 (2014).

    Article  CAS  Google Scholar 

  11. Daniels, M.A. et al. Nature 444, 724–729 (2006).

    Article  CAS  Google Scholar 

  12. McNeil, L.K., Starr, T.K. & Hogquist, K.A. Proc. Natl. Acad. Sci. USA 102, 13574–13579 (2005).

    Article  CAS  Google Scholar 

  13. Ross, J.O. et al. Proc. Natl. Acad. Sci. USA 111, E2550–E2558 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nicholas R J Gascoigne.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Brzostek, J., Gascoigne, N. Vive la peptide différence!. Nat Immunol 17, 896–898 (2016). https://doi.org/10.1038/ni.3507

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3507

  • Springer Nature America, Inc.

Navigation