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Tcf1 and Lef1 pack their own HDAC

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The transcription factors Tcf1 and Lef1 have intrinsic histone-deacetylase activity that is required for the repression of CD4+ T cell–lineage genes in CD8+ T cells.

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Figure 1: Tcf1 and Lef1 regulate gene expression in CD8+ thymocytes through intrinsic HDAC activity.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Charles P. Ng is with The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York, USA.,

    Charles P Ng

  2. Dan R. Littman is with The Kimmel Center for Biology and Medicine of the Skirball Institute and the Howard Hughes Medical Institute, New York University School of Medicine, New York, New York, USA.,

    Dan R Littman

Authors
  1. Charles P Ng
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  2. Dan R Littman
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Correspondence to Dan R Littman.

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The authors declare no competing financial interests.

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Ng, C., Littman, D. Tcf1 and Lef1 pack their own HDAC. Nat Immunol 17, 615–616 (2016). https://doi.org/10.1038/ni.3469

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