Skip to main content
Log in

The cell identity of cytotoxic T lymphocytes

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Understanding cytotoxic T cells has been a major focus of immunology research for decades. Proteomic profiling of these cells now brings them into unprecedented and revealing focus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Cell identity of CTLs.

References

  1. Schwanhäusser, B. et al. Nature 473, 337–342 (2011).

    Google Scholar 

  2. Hukelmann, J.L. et al. Nat. Immunol. 17, 104–112 (2016).

    Article  CAS  Google Scholar 

  3. Wiśniewski, J.R., Hein, M.Y., Cox, J. & Mann, M. Mol. Cell. Proteomics 13, 3497–3506 (2014).

    Article  Google Scholar 

  4. Isaaz, S., Baetz, K., Olsen, K., Podack, E. & Griffiths, G.M. Eur. J. Immunol. 25, 1071–1079 (1995).

    Article  CAS  Google Scholar 

  5. Buck, D., O'Sullivan, D. & Pearce, E.L. J. Exp. Med. 212, 1345–1360 (2015).

    Article  CAS  Google Scholar 

  6. Cham, C.M., Driessens, G., O'Keefe, J.P. & Gajewski, T.F. Eur. J. Immunol. 38, 2438–2450 (2008).

    Article  CAS  Google Scholar 

  7. Castello, A., Hentze, M.W. & Preiss, T. Trends Endocrinol. Metab. http://dx.doi.org/10.1016/j.tem.2015.09.012 (28 October 2015).

  8. Macintyre, A.N. et al. Cell Metab. 20, 61–72 (2014).

    Article  CAS  Google Scholar 

  9. Sinclair, L.V. et al. Nat. Immunol. 14, 500–508 (2013).

    Article  CAS  Google Scholar 

  10. Xu, X., Ye, L., Araki, K. & Ahmed, s Semin. Immunol. 24, 429–435 (2012).

    Article  CAS  Google Scholar 

  11. Intlekofer, A.M. et al. Nat. Immunol. 6, 1236–1244 (2005).

    Article  CAS  Google Scholar 

  12. Jha, A.K. et al. Immunity 42, 419–430 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Edward J Pearce.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sanin, D., Pearce, E. The cell identity of cytotoxic T lymphocytes. Nat Immunol 17, 45–46 (2016). https://doi.org/10.1038/ni.3350

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3350

  • Springer Nature America, Inc.

Navigation