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Biological sensors shed light on ligand geography

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Small, soluble, ubiquitous ligands are difficult to visualize. Schwab and colleagues have created a functional receptor reporter that gauges the in vivo concentration, location and biological action of sphingolipids.

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Figure 1: Detection of S1P signaling in the spleen.

References

  1. Ramos-Perez, W.D., Fang, V., Escalante-Alcalde, D., Cammer, M. & Schwab, S.R. Nat. Immunol. 16, 1245–1252 (2015).

    Article  CAS  Google Scholar 

  2. Rosen, H., Stevens, R.C., Hanson, M., Roberts, E. & Oldstone, M.B.A. Annu. Rev. Biochem. 82, 637–662 (2013).

    Article  CAS  Google Scholar 

  3. Liu, C.H. et al. Mol. Biol. Cell 10, 1179–1190 (1999).

    Article  CAS  Google Scholar 

  4. Groom, J.R. et al. Immunity 37, 1091–1103 (2012).

    Article  CAS  Google Scholar 

  5. O'Brien, N. et al. J. Lipid Res. 50, 2245–2257 (2009).

    Article  CAS  Google Scholar 

  6. Kono, M. et al. J. Clin. Invest. 124, 2076–2086 (2014).

    Article  CAS  Google Scholar 

  7. Cahalan, S.M. et al. Nat. Chem. Biol. 7, 254–256 (2011).

    Article  CAS  Google Scholar 

  8. Cyster, J.G. Science 286, 2098–2102 (1999).

    Article  CAS  Google Scholar 

  9. Mandala, S. et al. Science 296, 346–349 (2002).

    Article  CAS  Google Scholar 

  10. Cyster, J.G. & Schwab, S.R. Annu. Rev. Immunol. 30, 69–94 (2012).

    Article  CAS  Google Scholar 

  11. Shiow, L.R. et al. Nature 440, 540–544 (2006).

    Article  CAS  Google Scholar 

  12. Adada, M. M. et al. FASEB J. doi:10.1096/fj.15-274340 (24 July 2015).

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Authors and Affiliations

  1. the Department of Microbiology and Immunology, and the Department of Surgery, C. Colin Brinkman and Jonathan S. Bromberg are with the Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA, University of Maryland School of Medicine, Baltimore, Maryland, USA, University of Maryland School of Medicine, Baltimore, Maryland, USA.,

    C Colin Brinkman & Jonathan S Bromberg

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  1. C Colin Brinkman
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  2. Jonathan S Bromberg
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Correspondence to Jonathan S Bromberg.

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The authors declare no competing financial interests.

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Brinkman, C., Bromberg, J. Biological sensors shed light on ligand geography. Nat Immunol 16, 1209–1211 (2015). https://doi.org/10.1038/ni.3315

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