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De-Mst-ifying microbicidal killing

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Mitochondria can contribute to an increase in the amount of phagosomal reactive oxygen species and thereby promote the effective killing of bacteria. Study of mice deficient in Mst1 and Mst2 reveals a role for these kinases in recruiting mitochondria to phagosomes.

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Figure 1: Mst1/2 regulate the recruitment of mitochondria to phagosomes.

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Acknowledgements

The opinions expressed herein do not necessarily represent those of the Bill & Melinda Gates Foundation.

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Authors and Affiliations

  1. Lynda M. Stuart is with the Immunology Program, Benaroya Research Institutes, Seattle, Washington, USA, and Discovery & Translational Sciences, Bill & Melinda Gates Foundation, Seattle, Washington, USA.,

    Lynda M Stuart

  2. Adam Lacy-Hulbert is with the Immunology Program, Benaroya Research Institutes, Seattle, Washington, USA.,

    Adam Lacy-Hulbert

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  1. Lynda M Stuart
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  2. Adam Lacy-Hulbert
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Correspondence to Lynda M Stuart.

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Stuart, L., Lacy-Hulbert, A. De-Mst-ifying microbicidal killing. Nat Immunol 16, 1107–1108 (2015). https://doi.org/10.1038/ni.3291

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