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Genomics is rapidly advancing precision medicine for immunological disorders

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Advances in human genomics, when validated functionally, can lead to new insights into how the immune system works. Notably, previously unknown mechanisms revealed by genomics can lead to the development of precision medicine unanticipated on the basis of phenotype alone.

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Figure 1
Figure 2: Modes of inheritance.

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Acknowledgements

Supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (US National Institutes of Health).

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Authors and Affiliations

  1. Yu Zhang is with Human Immunological Diseases Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, and Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.,

    Yu Zhang

  2. Helen C. Su is with Human Immunological Diseases Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, and National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.,

    Helen C Su

  3. Michael J. Lenardo is with National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, and Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.,

    Michael J Lenardo

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  1. Yu Zhang
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  2. Helen C Su
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Correspondence to Michael J Lenardo.

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Zhang, Y., Su, H. & Lenardo, M. Genomics is rapidly advancing precision medicine for immunological disorders. Nat Immunol 16, 1001–1004 (2015). https://doi.org/10.1038/ni.3275

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