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Reading the fine print: sequence-specific activation of cGAS

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A unique guanosine-flanked Y-form DNA triggers innate cGAS-dependent responses that lead to upregulation of the production of type I interferons.

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Figure 1: The recognition of Y-form DNA containing unpaired guanosines by cGAS.

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Authors and Affiliations

  1. Jessica J. Chiang is in the Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.,

    Jessica J Chiang

  2. Michaela U. Gack is in the Department of Microbiology and Immunobiology, and the Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA, University of Chicago, Chicago, Illinois, USA.,

    Michaela U Gack

Authors
  1. Jessica J Chiang
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  2. Michaela U Gack
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Correspondence to Michaela U Gack.

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The authors declare no competing financial interests.

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Chiang, J., Gack, M. Reading the fine print: sequence-specific activation of cGAS. Nat Immunol 16, 1009–1010 (2015). https://doi.org/10.1038/ni.3274

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