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Subversion of anticancer immunosurveillance by radiotherapy

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Paradoxically, radiotherapy can reinforce immunosuppressive pathways that undermine anticancer immunosurveillance and treatment efficacy. Irradiation induces Langerhans cells to migrate from the skin to lymph nodes, where they stimulate regulatory T cells.

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Figure 1: Immunological effects of radiotherapy.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Laurence Zitvogel is with the Gustave Roussy Cancer Campus, Villejuif, France,

    Laurence Zitvogel

  2. Inserm U1015, Villejuif, France, Université Paris Sud-XI, Faculté de Médecine, Le Kremlin Bicêtre, France,

    Laurence Zitvogel

  3. Guido Kroemer is with Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Inserm U1138, Paris, France,

    Guido Kroemer

  4. Université Paris Descartes, Sorbonne Paris Cité, Paris, France,

    Guido Kroemer

  5. Université Pierre et Marie Curie, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publiques–Hôpitaux de Paris, Paris, France; and Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.,

    Guido Kroemer

  6. the Center of Clinical Investigations in Biotherapies of Cancer 507, Villejuif, France.,

    Laurence Zitvogel

  7. Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publiques–Hôpitaux de Paris, Paris, France,

    Guido Kroemer

  8. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.,

    Guido Kroemer

Authors
  1. Laurence Zitvogel
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  2. Guido Kroemer
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Corresponding author

Correspondence to Laurence Zitvogel.

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The authors declare no competing financial interests.

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Zitvogel, L., Kroemer, G. Subversion of anticancer immunosurveillance by radiotherapy. Nat Immunol 16, 1005–1007 (2015). https://doi.org/10.1038/ni.3236

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