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TET1: an epigenetic guardian of lymphomagenesis

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Due to their role in regulating DNA-methylation patterns, the TET proteins, in particular TET2, have emerged as key participants in tumorigenesis. Now the spotlight shifts to TET1 and its role as a tumor suppressor in lymphomagenesis.

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Figure 1: The role of TET1 in regulating DNA methylation and hematopoiesis.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Kasper Dindler Rasmussen is with the Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark, and the Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark.,

    Kasper Dindler Rasmussen

  2. Kristian Helin is with the Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark, the Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark, and The Danish Stem Cell Centre, University of Copenhagen, Copenhagen, Denmark.,

    Kristian Helin

Authors
  1. Kasper Dindler Rasmussen
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  2. Kristian Helin
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Correspondence to Kristian Helin.

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The authors declare no competing financial interests.

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Rasmussen, K., Helin, K. TET1: an epigenetic guardian of lymphomagenesis. Nat Immunol 16, 592–594 (2015). https://doi.org/10.1038/ni.3176

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