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Brainless immunity no more

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The mediobasal hypothalamus detects increased amounts of tumor necrosis factor during the early phases of inflammation and relays this information to cells of the adaptive immune system by mobilizing free fatty acids.

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Figure 1: The hypothalamus activates adaptive immunity through lipolysis.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Department of Neuroscience, Sachin P. Gadani and Jonathan Kipnis are in the Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.,

    Sachin P Gadani & Jonathan Kipnis

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  1. Sachin P Gadani
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  2. Jonathan Kipnis
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Correspondence to Jonathan Kipnis.

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Gadani, S., Kipnis, J. Brainless immunity no more. Nat Immunol 16, 440–441 (2015). https://doi.org/10.1038/ni.3145

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