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Sox2 as a servant of two masters

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The transcription factor Sox2 has an additional function in neutrophils, as a cytoplasmic sensor of DNA. Upon binding bacterial DNA, Sox2 initiates a signaling cascade dependent on the kinase TAK1 and adaptor TAB2 that culminates in the expression of genes encoding pro-inflammatory molecules.

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Figure 1: Sensors of dsDNA in macrophages and neutrophils.

Katie Vicari/Nature Publishing Group

References

  1. Wu, J. & Chen, Z.J. Annu. Rev. Immunol. 32, 461–488 (2014).

    Article  CAS  Google Scholar 

  2. Xia, P. et al. Nat. Immunol. 16, 366–375 (2015).

    Article  CAS  Google Scholar 

  3. Sarkar, A. & Hochedlinger, K. Cell Stem Cell 12, 15–30 (2013).

    Article  CAS  Google Scholar 

  4. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  5. Kamachi, Y. & Kondoh, H. Development 140, 4129–4144 (2013).

    Article  CAS  Google Scholar 

  6. Chen, Z.J. Immunol. Rev. 246, 95–106 (2012).

    Article  Google Scholar 

  7. Hornung, V. & Latz, E. Nat. Rev. Immunol. 10, 123–130 (2010).

    Article  CAS  Google Scholar 

  8. Hornung, V., Hartmann, R., Ablasser, A. & Hopfner, K.P. Nat. Rev. Immunol. 14, 521–528 (2014).

    Article  CAS  Google Scholar 

  9. Abe, T. & Barber, G.N. J. Virol. 88, 5328–5341 (2014).

    Article  Google Scholar 

  10. Yanai, H., Ban, T. & Taniguchi, T. Trends Immunol. 33, 633–640 (2012).

    Article  CAS  Google Scholar 

  11. Bianchi, M.E. & Manfredi, A.A. Immunol. Rev. 220, 35–46 (2007).

    Article  CAS  Google Scholar 

  12. Yasuhara, N. et al. Nat. Cell Biol. 9, 72–79 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Arun K. Mankan and Veit Hornung are at the Institute of Molecular Medicine, University Hospital, University of Bonn, Bonn, Germany.,

    Arun K Mankan & Veit Hornung

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  1. Arun K Mankan
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  2. Veit Hornung
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Correspondence to Veit Hornung.

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Mankan, A., Hornung, V. Sox2 as a servant of two masters. Nat Immunol 16, 335–336 (2015). https://doi.org/10.1038/ni.3121

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