Skip to main content

Advertisement

Log in

GPR15: a tale of two species

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

The chemoattractant receptor GPR15 directs the homing of T cells to the colon; however, GRP15 expression differs in the effector and regulatory T cell subsets of humans versus those of mice. These findings have profound implications for the potential targeting of GRP15 for therapeutic intervention.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Divergent expression of GPR15 in subsets of Teff cells and Treg cells in humans and mice.

Marina Corral Spence/Nature Publishing Group

References

  1. Nguyen, L.P. et al. Nat. Immunol. 16, 207–213 (2015).

    Article  CAS  Google Scholar 

  2. Kim, S.V. et al. Science 340, 1456–1459 (2013).

    Article  CAS  Google Scholar 

  3. Mosli, M.H., Rivera-Nieves, J. & Feagan, B.G. Drugs 74, 297–311 (2014).

    Article  CAS  Google Scholar 

  4. Poole, R.M. Drugs 74, 1293–1303 (2014).

    Article  CAS  Google Scholar 

  5. Keshav, S. et al. PLoS ONE 8, e60094 (2013).

    Article  CAS  Google Scholar 

  6. Heiber, M. et al. Genomics 32, 462–465 (1996).

    Article  CAS  Google Scholar 

  7. Deng, H.K. & Unutmaz, D. KewalRamani, V.N. & Littman, D.R. Nature 388, 296–300 (1997).

    Article  CAS  Google Scholar 

  8. Farzan, M. et al. J. Biol. Chem. 272, 6854–6857 (1997).

    Article  CAS  Google Scholar 

  9. Soriano, A. et al. Lab. Invest. 80, 1541–1551 (2000).

    Article  CAS  Google Scholar 

  10. Fiorucci, S. et al. Immunity 17, 769–780 (2002).

    Article  CAS  Google Scholar 

  11. Wang, C. et al. Inflamm. Bowel Dis. 16, 1751–1762 (2010).

    Article  Google Scholar 

  12. Denning, T.L., Kim, G. & Kronenberg, M. J. Immunol. 174, 7487–7491 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joanne L Viney.

Ethics declarations

Competing interests

J.L.V. is employed by Biogen Idec.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bilsborough, J., Viney, J. GPR15: a tale of two species. Nat Immunol 16, 137–139 (2015). https://doi.org/10.1038/ni.3084

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3084

  • Springer Nature America, Inc.

Navigation