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Stop the executioners

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Virus-triggered type I interferon induces the lysine methyltransferase Setdb2; this then generates repressive histone marks on the promoters of genes encoding molecules important for antibacterial immunity. This process can contribute to influenza virus–associated bacterial superinfection.

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Figure 1: Infection with influenza virus reduces the immune response to secondary bacterial infection by a Setdb2-dependent mechanism.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Division of Immunoregulation, Medical Research Council, National Institute for Medical Research, Mill Hill, London, UK

    Andreas Wack

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  1. Andreas Wack
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Correspondence to Andreas Wack.

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Wack, A. Stop the executioners. Nat Immunol 16, 6–8 (2015). https://doi.org/10.1038/ni.3055

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