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A surprising role for TLR7

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Ligation of the Toll-like receptor TLR7 in human CD4+ T cells elicits an anergic state that may contribute to CD4+ T cell hyporesponsiveness after infection with human immunodeficiency virus type 1 and may also enhance propagation of this virus.

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Figure 1: The engagement of TLR7 in isolated CD4+ T cells induces an anergic state and promotes HIV-1 replication.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Michael M. Lederman is with Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA.,

    Michael M Lederman

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  1. Michael M Lederman
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Correspondence to Michael M Lederman.

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Lederman, M. A surprising role for TLR7. Nat Immunol 16, 8–9 (2015). https://doi.org/10.1038/ni.3051

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