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Continued mission of ThPOK

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ThPOK, the critical transcription factor for differentiation of the helper T cell lineage in the thymus, continues to function as a gatekeeper to maintain helper T cell identity by repressing the transcription factor Runx3 in mature T cells.

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Figure 1: ThPOK maintains the helper-lineage integrity through repression of Runx3.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Takeshi Egawa is in the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.,

    Takeshi Egawa

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  1. Takeshi Egawa
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Correspondence to Takeshi Egawa.

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Egawa, T. Continued mission of ThPOK. Nat Immunol 15, 900–902 (2014). https://doi.org/10.1038/ni.2988

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