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Chemokine 'grooming' by cLECs directs DC migration

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Migrating dendritic cells follow precise navigational chemokine gradients established by lymph node stromal cells through their asymmetric expression of the atypical chemokine receptor CCRL1.

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Figure 1: The cLECs shape chemokine gradients in the lymph nodes via CCRL1.

Debbie Maizels/Nature Publishing Group

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Correspondence to Shannon J Turley.

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Woodruff, M., Turley, S. Chemokine 'grooming' by cLECs directs DC migration. Nat Immunol 15, 595–596 (2014). https://doi.org/10.1038/ni.2926

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