The activation of dendritic cells by Toll-like receptors leads to a rapid enhancement in glycolysis. Glucose is metabolized to pyruvate and from there to citrate in the mitochondria, which leads ultimately to membrane biosynthesis in the endoplasmic reticulum and Golgi to support the activation of dendritic cells.
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O'Neill, L. Glycolytic reprogramming by TLRs in dendritic cells. Nat Immunol 15, 314–315 (2014). https://doi.org/10.1038/ni.2852
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DOI: https://doi.org/10.1038/ni.2852
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