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TCR signaling: the barrier within

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Acute inhibition of the regulatory kinase Csk reveals additional checkpoints for full activation of thymocytes via the T cell antigen receptor.

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Figure 1: Effects of Csk inhibition and actin disruption on TCR signaling.

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Authors and Affiliations

  1. Michael L. Dustin is with the Kennedy Institute of Rheumatology and Nuffield Department of Orthopedics and Musculoskeletal Sciences, The University of Oxford, Oxford, UK.,

    Michael L Dustin

  2. Simon J. Davis is with the Medical Research Council Human Immunology Unit and Radcliffe Department of Clinical Medicine, Weatherall Institute of Molecular Medicine, The University of Oxford, Oxford, UK.,

    Simon J Davis

Authors
  1. Michael L Dustin
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  2. Simon J Davis
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Correspondence to Michael L Dustin.

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The authors declare no competing financial interests.

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Dustin, M., Davis, S. TCR signaling: the barrier within. Nat Immunol 15, 136–137 (2014). https://doi.org/10.1038/ni.2811

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