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Outflanking HCV

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Studies have linked polymorphisms near the gene encoding interferon-λ3 (IFNL3) to clearance of hepatitis C virus (HCV). One such favorable polymorphism operates by stabilizing IFNL3 mRNA via a decrease in AU-rich element–mediated decay as well as the binding of HCV-induced host microRNAs.

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Figure 1: The role of HCV-induced miRNAs in HCV clearance.

References

  1. Suppiah, V. et al. Nat. Genet. 41, 1100–1104 (2009).

    Article  CAS  Google Scholar 

  2. Tanaka, Y. et al. Nat. Genet. 41, 1105–1109 (2009).

    Article  CAS  Google Scholar 

  3. Ge, D. et al. Nature 461, 399–401 (2009).

    Article  CAS  Google Scholar 

  4. Thomas, D.L. et al. Nature 461, 798–801 (2009).

    Article  CAS  Google Scholar 

  5. McFarland, A. et al. Nat. Immunol. 15, 72–79 (2014).

    Article  CAS  Google Scholar 

  6. Thomas, D.L. Nat. Med. 19, 850–858 (2013).

    Article  CAS  Google Scholar 

  7. Rehermann, B. Nat. Med. 19, 859–868 (2013).

    Article  CAS  Google Scholar 

  8. Lanford, R.E. et al. Science 327, 198–201 (2010).

    Article  CAS  Google Scholar 

  9. Janssen, H.L. et al. N. Engl. J. Med. 368, 1685–1694 (2013).

    Article  CAS  Google Scholar 

  10. Knapp, S. et al. Hepatology 51, 1168–1175 (2010).

    Article  CAS  Google Scholar 

  11. Rehermann, B. & Nascimbeni, M. Nat. Rev. Immunol. 5, 215–229 (2005).

    Article  CAS  Google Scholar 

  12. Arzumanyan, A., Reis, H.M. & Feitelson, M.A. Nat. Rev. Cancer 13, 123–135 (2013).

    Article  CAS  Google Scholar 

  13. Holder, K.A., Stapleton, S.N., Gallant, M.E., Russell, R.S. & Grant, M.D. J. Immunol. 191, 3308–3318 (2013).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Zhigang Tian is with the Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China.,

    Zhigang Tian

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  1. Zhigang Tian
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Correspondence to Zhigang Tian.

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Tian, Z. Outflanking HCV. Nat Immunol 15, 6–8 (2014). https://doi.org/10.1038/ni.2783

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