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A HESitant decision for T cells

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Precursor cells entering the thymus have non-T cell potential, yet T cell development is clearly favored. A mechanism dedicated to repressing conflicting myeloid cell fate early during the establishment of T cell identity has now been found.

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Figure 1: Positive and negative gene circuits that control early T cell differentiation.

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Authors and Affiliations

  1. Alexandra Bortnick and Cornelis Murre are in the Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA.,

    Alexandra Bortnick & Cornelis Murre

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  1. Alexandra Bortnick
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  2. Cornelis Murre
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Correspondence to Cornelis Murre.

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The authors declare no competing financial interests.

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Bortnick, A., Murre, C. A HESitant decision for T cells. Nat Immunol 14, 1209–1210 (2013). https://doi.org/10.1038/ni.2765

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