Skip to main content
SpringerLink
Log in

Influenza vaccines: mTOR inhibition surprisingly leads to protection

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Mice immunized with influenza virus in the presence of rapamycin, which blocks the formation of germinal centers, make mostly IgM antibodies that protect against infection with multiple subtypes of influenza virus, including avian viruses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Rapamycin enhances IgM responses.

References

  1. Watanabe, T. et al. Nature 501, 551–555 (2013).

    Article  CAS  Google Scholar 

  2. Whittle, J.R. et al. Proc. Natl. Acad. Sci. USA 108, 14216–14221 (2011).

    Article  CAS  Google Scholar 

  3. Kanekiyo, M. et al. Nature 499, 102–106 (2013).

    Article  CAS  Google Scholar 

  4. Keating, R. et al. Nat. Immunol. 14, 1266–1276 (2013).

    Article  CAS  Google Scholar 

  5. Chiu, M.I., Katz, H. & Berlin, V. Proc. Natl. Acad. Sci. USA 91, 12574–12578 (1994).

    Article  CAS  Google Scholar 

  6. Brown, E.J. et al. Nature 369, 756–758 (1994).

    Article  CAS  Google Scholar 

  7. Rajewsky, K., Forster, I. & Cumano, A. Science 238, 1088–1094 (1987).

    Article  CAS  Google Scholar 

  8. Muramatsu, M. et al. Cell 102, 553–563 (2000).

    Article  CAS  Google Scholar 

  9. Garrity, R.R. et al. J. Immunol. 159, 279–289 (1997).

    CAS  PubMed  Google Scholar 

  10. Nara, P.L. et al. PLoS Biol. 8, e1000571 (2010).

    Article  CAS  Google Scholar 

  11. Yewdell, J.W. Immunity 25, 533–543 (2006).

    Article  CAS  Google Scholar 

  12. Zinkernagel, R.M. Science 271, 173–178 (1996).

    Article  CAS  Google Scholar 

  13. Mascola, J.R. & Haynes, B.F. Immunol. Rev. 254, 225–244 (2013).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Andrew J. McMichael is with the Nuffield Department of Medicine, University of Oxford, Oxford, UK.,

    Andrew J McMichael

  2. Barton F. Haynes is with the Department of Medicine, Human Vaccine Institute, Duke University, Durham, North Carolina, USA.,

    Barton F Haynes

Authors
  1. Andrew J McMichael
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Barton F Haynes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrew J McMichael.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

McMichael, A., Haynes, B. Influenza vaccines: mTOR inhibition surprisingly leads to protection. Nat Immunol 14, 1205–1207 (2013). https://doi.org/10.1038/ni.2764

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2764

  • Springer Nature America, Inc.

Search

Navigation