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Loss of translation: a stealth weapon against pathogens?

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Various receptors alert cells to microbial invasion through the detection of conserved molecular patterns and initiate innate immunity. During infection with Legionella pneumophila, macrophages modulate cytokine responses by downregulating protein synthesis according to the pathogenic potential of the intruder.

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Figure 1: Breaching of the endosome by pathogenic Legionella promotes inflammation.

Debbie Maizels

References

  1. Ishii, K.J., Koyama, S., Nakagawa, A., Coban, C. & Akira, S. Cell Host Microbe 3, 352–363 (2008).

    Article  CAS  Google Scholar 

  2. Ivanov, S.S. & Roy, C.R. Nat. Immunol. 14, 1219–1228 (2013).

    Article  CAS  Google Scholar 

  3. Mohr, I. & Sonenberg, N. Cell Host Microbe 12, 470–483 (2012).

    Article  CAS  Google Scholar 

  4. Pierre, P. Curr. Opin. Immunol. 21, 70–77 (2009).

    Article  CAS  Google Scholar 

  5. Ceppi, M. et al. Immunome Res. 5, 5 (2009).

    Article  Google Scholar 

  6. Colina, R. et al. Nature 452, 323–328 (2008).

    Article  CAS  Google Scholar 

  7. Schmidt, E.K., Clavarino, G., Ceppi, M. & Pierre, P. Nat. Methods 6, 275–277 (2009).

    Article  CAS  Google Scholar 

  8. Lemaitre, B. & Girardin, S.E. Nat. Rev. Microbiol. 11, 365–369 (2013).

    Article  CAS  Google Scholar 

  9. McEwan, D.L., Kirienko, N.V. & Ausubel, F.M. Cell Host Microbe 11, 364–374 (2012).

    Article  CAS  Google Scholar 

  10. Dunbar, T.L., Yan, Z., Balla, K.M., Smelkinson, M.G. & Troemel, E.R. Cell Host Microbe 11, 375–386 (2012).

    Article  CAS  Google Scholar 

  11. Araki, K., Ellebedy, A.H. & Ahmed, R. Curr. Opin. Cell Biol. 23, 707–715 (2011).

    Article  CAS  Google Scholar 

  12. Lelouard, H. et al. J. Cell Biol. 179, 1427–1439 (2007).

    Article  CAS  Google Scholar 

  13. Herdy, B. et al. Nat. Immunol. 13, 543–550 (2012).

    Article  CAS  Google Scholar 

  14. Vance, R.E., Isberg, R.R. & Portnoy, D.A. Cell Host Microbe 6, 10–21 (2009).

    Article  CAS  Google Scholar 

  15. Fontana, M.F. et al. PLoS Pathog. 7, e1001289 (2011).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Marseille, France

    Philippe Pierre & Evelina Gatti

  2. INSERM, Marseille, U1104, France

    Philippe Pierre & Evelina Gatti

  3. CNRS, UMR, Marseille, 7280, France

    Philippe Pierre & Evelina Gatti

Authors
  1. Philippe Pierre
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  2. Evelina Gatti
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Correspondence to Philippe Pierre or Evelina Gatti.

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The authors declare no competing financial interests.

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Pierre, P., Gatti, E. Loss of translation: a stealth weapon against pathogens?. Nat Immunol 14, 1203–1205 (2013). https://doi.org/10.1038/ni.2759

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  • DOI: https://doi.org/10.1038/ni.2759

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