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Bypassing T cell 'exhaustion'

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The hypoxia-inducible factor (HIF) pathway controls diverse aspects of the immunological response. Enhanced HIF activity is able to extend and potentiate the effector response of CD8+ T cells against chronic infections and tumor growth.

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Figure 1: Enhanced HIF signaling drives an activated effector fate of CD8+ T cells and counteracts exhaustion in response to chronic exposure to antigen.

Katie Vicari

References

  1. Wherry, E.J. Nat. Immunol. 12, 492–499 (2011).

    Article  CAS  PubMed  Google Scholar 

  2. Kao, C. et al. Nat. Immunol. 12, 663–671 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Shin, H. et al. Immunity 31, 309–320 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Doedens, A.L. et al. Nat. Immunol. 14, 1173–1182 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Dang, E.V. et al. Cell 146, 772–784 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Shi, L.Z. et al. J. Exp. Med. 208, 1367–1376 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Li, M. & Kim, W.Y. J. Cell. Mol. Med. 15, 187–195 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wherry, E.J. et al. Immunity 27, 670–684 (2007).

    CAS  PubMed  Google Scholar 

  9. Kaech, S.M. & Cui, W. Nat. Rev. Immunol. 12, 749–761 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Paley, M.A. et al. Science 338, 1220–1225 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Zhou, X. et al. Immunity 33, 229–240 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Baitsch, L. et al. J. Clin. Invest. 121, 2350–2360 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Zhou, Q. et al. Blood 117, 4501–4510 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Göthert, J.R. et al. Cancer Immunol. Immunother. (2013).

  15. McNamee, E.N., Korns, J.D., Homann, D. & Clambey, E.T. Immunol. Res. 55, 58–70 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Joachim R. Göthert is with the Department of Hematology, West German Cancer Center, University Hospital of Essen, Essen, Germany.,

    Joachim R Göthert

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  1. Joachim R Göthert
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Correspondence to Joachim R Göthert.

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Göthert, J. Bypassing T cell 'exhaustion'. Nat Immunol 14, 1114–1116 (2013). https://doi.org/10.1038/ni.2742

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