Skip to main content

Advertisement

SpringerLink
Log in

You break it, you fix it: functions for AID downstream of deamination

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

In a phosphorylation-dependent positive feedback loop, the cytidine deaminase AID amplifies the generation of double-strand DNA breaks, which shows it can also function downstream of deamination.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Two roles for AID during CSR.

References

  1. Keim, C., Kazadi, D., Rothschild, G. & Basu, U. Genes Dev. 27, 1–17 (2013).

    Article  CAS  Google Scholar 

  2. Vuong, B.Q. et al. Nat. Immunol. 14, 1183–1189 (2013).

    Article  CAS  Google Scholar 

  3. Stavnezer, J. & Schrader, C.E. Trends Genet. 22, 23–28 (2006).

    Article  CAS  Google Scholar 

  4. Xu, Z., Zan, H., Pone, E.J., Mai, T. & Casali, P. Nat. Rev. Immunol. 12, 517–531 (2012).

    Article  CAS  Google Scholar 

  5. Cheng, H.-L. et al. Proc. Natl. Acad. Sci. USA 106, 2717–2722 (2009).

    Article  CAS  Google Scholar 

  6. Basu, U. et al. Biochem. Soc. Trans. 37, 561–568 (2009).

    Article  CAS  Google Scholar 

  7. Chaudhuri, J., Khuong, C. & Alt, F.W. Nature 430, 992–998 (2004).

    Article  CAS  Google Scholar 

  8. Basu, U. et al. Nature 438, 508–511 (2005).

    Article  CAS  Google Scholar 

  9. Vuong, B.Q. et al. Nat. Immunol. 10, 420–426 (2009).

    Article  CAS  Google Scholar 

  10. Yamane, A. et al. Cell Rep 3, 138–147 (2013).

    Article  CAS  Google Scholar 

  11. Mimitou, E.P. & Symington, L.S. DNA Repair (Amst.) 10, 344–348 (2011).

    Article  CAS  Google Scholar 

  12. Chen, H., Lisby, M. & Symington, L.S. Mol. Cell 50, 589–600 (2013).

    Article  CAS  Google Scholar 

  13. Litman, G.W., Cannon, J.P. & Rast, J.P. Adv. Immunol. 87, 209–236 (2005).

    Article  CAS  Google Scholar 

  14. Flajnik, M.F. & Kasahara, M. Nat. Rev. Genet. 11, 47–59 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rebecca K. Delker is with the Laboratory of Lymphocyte Biology, The Rockefeller University, New York, New York, USA, and The Rockefeller Graduate Program, The Rockefeller University, New York, New York, USA.,

    Rebecca K Delker

  2. F. Nina Papavasiliou is with the Laboratory of Lymphocyte Biology, The Rockefeller University, New York, New York, USA.,

    F Nina Papavasiliou

Authors
  1. Rebecca K Delker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F Nina Papavasiliou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to F Nina Papavasiliou.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Delker, R., Papavasiliou, F. You break it, you fix it: functions for AID downstream of deamination. Nat Immunol 14, 1112–1114 (2013). https://doi.org/10.1038/ni.2738

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2738

  • Springer Nature America, Inc.

Search

Navigation