Abstract
Helminth infections are ubiquitous worldwide and can trigger potent immune responses that differ from and potentially antagonize host protective responses to microbial pathogens. In this Review we focus on the three main killers in infectious disease—AIDS, tuberculosis and malaria—and critically assesses whether helminths adversely influence host control of these diseases. We also discuss emerging concepts for how M2 macrophages and helminth-modulated dendritic cells can potentially influence the protective immune response to concurrent infections. Finally, we present evidence advocating for more efforts to determine how and to what extent helminths interfere with the successful control of specific concurrent coinfections.
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Acknowledgements
We thank T. Nutman for critical comments on this manuscript. Supported by the US National Institutes of Health (AI031678 and AIO66188 to W.C.G., AI065663 and A1069395 to P.S. and AI83405 to G.S.Y.).
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Salgame, P., Yap, G. & Gause, W. Effect of helminth-induced immunity on infections with microbial pathogens. Nat Immunol 14, 1118–1126 (2013). https://doi.org/10.1038/ni.2736
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DOI: https://doi.org/10.1038/ni.2736
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