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IFN-β-specific signaling via a unique IFNAR1 interaction

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A unique complex of the interferon receptor IFNAR1 and interferon-β (IFN-β) has been identified that signals independently of IFNAR2 and induces a distinct set of interferon-inducible genes and downstream IFN-β-specific functional responses.

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Figure 1: Potential model for the regulation of interferon-stimulated gene (ISG) expression after binding of IFN-β or IFN-α to the type I IFNR complex.

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Authors and Affiliations

  1. Feinberg School of Medicine and Department of Medicine, Surinder Kaur and Leonidas C. Platanias are with the Robert H. Lurie Comprehensive Cancer Center Northwestern University, Jesse Brown Virginia Medical Center, Chicago, Illinois, USA.,

    Surinder Kaur & Leonidas C Platanias

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  1. Surinder Kaur
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  2. Leonidas C Platanias
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Correspondence to Leonidas C Platanias.

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The authors declare no competing financial interests.

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Kaur, S., Platanias, L. IFN-β-specific signaling via a unique IFNAR1 interaction. Nat Immunol 14, 884–885 (2013). https://doi.org/10.1038/ni.2686

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