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Deconstructing development

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An algorithm developed with a systems-biology approach reconstructs some of the key regulatory events known to drive the development of cells of the mouse immune system and makes many other novel predictions for testing.

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Figure 1: Modules and their regulators.

Katie Vicari

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Authors and Affiliations

  1. Christelle Harly and Avinash Bhandoola are in the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.,

    Christelle Harly & Avinash Bhandoola

  2. E. John Wherry is in the Department of Microbiology, Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.,

    E John Wherry

Authors
  1. Christelle Harly
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  2. E John Wherry
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  3. Avinash Bhandoola
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Correspondence to Avinash Bhandoola.

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The authors declare no competing financial interests.

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Harly, C., Wherry, E. & Bhandoola, A. Deconstructing development. Nat Immunol 14, 529–531 (2013). https://doi.org/10.1038/ni.2613

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