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Slc7a5 helps T cells get with the program

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T cell activation requires an influx of amino acids. Slc7a5, an amino-acid transporter induced by the T cell antigen receptor, facilitates the influx of large neutral amino acids and in doing so promotes metabolic reprogramming necessary for T cell differentiation.

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Figure 1: Slc7a5 promotes the proliferation and differentiation of T cells by reprogramming metabolism.

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Authors and Affiliations

  1. Jonathan D. Powell is in the Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.,

    Jonathan D Powell

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  1. Jonathan D Powell
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Correspondence to Jonathan D Powell.

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The author declares no competing financial interests.

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Powell, J. Slc7a5 helps T cells get with the program. Nat Immunol 14, 422–424 (2013). https://doi.org/10.1038/ni.2594

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