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Changing course by lymphocyte lineage redirection

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The fate of T cells differentiating into the CD4 or CD8 lineage is typically fixed when cells leave the thymus. However, CD4+ helper T cells can be reprogrammed to develop into CD4+CD8α+ cytotoxic T lymphocytes in the gut.

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Figure 1: The generation and activation of CD4+CD8α+ cytotoxic T cells in the intestine.

Marina Corral

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Authors and Affiliations

  1. Michele K. Anderson is in the Department of Immunology, Division of Biology, Sunnybrook Research Institute, University of Toronto, Toronto, Canada.,

    Michele K Anderson

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  1. Michele K Anderson
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Correspondence to Michele K Anderson.

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Anderson, M. Changing course by lymphocyte lineage redirection. Nat Immunol 14, 199–201 (2013). https://doi.org/10.1038/ni.2544

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