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Just say NO to NLRP3

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Feedback inhibition by interferon-γ blocks the NLRP3 inflammasome by triggering inducible nitric oxide synthase (iNOS), and the resulting nitric oxide (NO) thio-nitrosylates NLRP3, shutting it down. This prevents excessive immunopathology during chronic infection with Mycobacterium tuberculosis.

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Figure 1: Thio-nitrosylation by NO inhibits the NLRP3 inflammasome.

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Authors and Affiliations

  1. Manira Rayamajhi and Edward A. Miao are in the Department of Microbiology and Immunology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Manira Rayamajhi & Edward A Miao

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  1. Manira Rayamajhi
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  2. Edward A Miao
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Correspondence to Edward A Miao.

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The authors declare no competing financial interests.

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Rayamajhi, M., Miao, E. Just say NO to NLRP3. Nat Immunol 14, 12–14 (2013). https://doi.org/10.1038/ni.2493

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