Skip to main content
SpringerLink
Log in

IL-2 and IL-15 signaling complexes: different but the same

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Interleukin 2 (IL-2) and IL-15 use receptors with the same signaling subunits. New structural data show that the signaling complexes they form are topologically nearly identical, which suggests that other factors are responsible for the distinct signaling properties of these complexes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Signaling by IL-2 and IL-15.

Debbie Maizels

References

  1. Wang, X., Lupardus, P., Laporte, S.L. & Garcia, K.C. Annu. Rev. Immunol. 27, 29–60 (2009).

    Article  Google Scholar 

  2. Ring, A.M. et al. Nat. Immunol. 13, 1187–1195 (2012).

    Article  CAS  Google Scholar 

  3. Murray, P.J. J. Immunol. 178, 2623–2629 (2007).

    Article  CAS  Google Scholar 

  4. Waldmann, T.A. Nat. Rev. Immunol. 6, 595–601 (2006).

    Article  CAS  Google Scholar 

  5. Chirifu, M. et al. Nat. Immunol. 8, 1001–1007 (2007).

    Article  CAS  Google Scholar 

  6. Olsen, S.K. et al. J. Biol. Chem. 282, 37191–37204 (2007).

    Article  CAS  Google Scholar 

  7. Wang, X., Rickert, M. & Garcia, K.C. Science 310, 1159–1163 (2005).

    Article  CAS  Google Scholar 

  8. Mortier, E. et al. Immunity 31, 811–822 (2009).

    Article  CAS  Google Scholar 

  9. Liparoto S.F. et al. (2002). Biochemistry 41, 2543–2551 (2002).

    Article  CAS  Google Scholar 

  10. Mortier, E. et al. J. Biol. Chem. 281, 1612–1619 (2006).

    Article  CAS  Google Scholar 

  11. Thomas, C. et al. Cell 146, 621–632 (2011).

    Article  CAS  Google Scholar 

  12. Huang, J. et al. Nature 464, 932–936 (2010)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shinji Ikemizu and Mami Chirifu are in the Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.,

    Shinji Ikemizu & Mami Chirifu

  2. Radcliffe Department of Medicine, Simon J. Davis and, at present, Mami Chirifu are at the Weatherall Institute of Molecular Medicine and Medical Research Council Human Immunology Unit, Oxford, UK.,

    Mami Chirifu & Simon J Davis

Authors
  1. Shinji Ikemizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mami Chirifu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Simon J Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Shinji Ikemizu or Simon J Davis.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ikemizu, S., Chirifu, M. & Davis, S. IL-2 and IL-15 signaling complexes: different but the same. Nat Immunol 13, 1141–1142 (2012). https://doi.org/10.1038/ni.2472

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2472

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation