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A voltage-gated sodium channel mediates positive selection of T cells

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The activation of T cells requires the entry of calcium ions through the plasma membrane. A study now identifies a voltage-gated sodium channel as being essential for the sustained entry of calcium needed for the developmental process of positive selection.

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Figure 1: Models for the entry of Ca2+ into mature and developing CD4+ T cells.

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Authors and Affiliations

  1. Bernard Malissen is at the Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7280, Marseille, France.,

    Bernard Malissen

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  1. Bernard Malissen
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Correspondence to Bernard Malissen.

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Malissen, B. A voltage-gated sodium channel mediates positive selection of T cells. Nat Immunol 13, 810–812 (2012). https://doi.org/10.1038/ni.2400

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