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Tumor immunity times out: TIM-3 and HMGB1

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The characteristics of the tumor microenvironment vary widely. New work shows that after tumor-associated expression of the receptor TIM-3 by dendritic cells, TIM-3 inhibits the antitumor efficacy of DNA vaccines and chemotherapy by binding to the damage-associated molecular pattern molecule, HMGB1.

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Figure 1: TIM-3 serves as a major regulator of immunity.

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Authors and Affiliations

  1. Daolin Tang is in the Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.,

    Daolin Tang

  2. Michael T. Lotze is in the Department of Surgery, Department of Immunology and Department of Bioengineering, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.,

    Michael T Lotze

Authors
  1. Daolin Tang
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  2. Michael T Lotze
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Correspondence to Daolin Tang or Michael T Lotze.

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The authors declare no competing financial interests.

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Tang, D., Lotze, M. Tumor immunity times out: TIM-3 and HMGB1. Nat Immunol 13, 808–810 (2012). https://doi.org/10.1038/ni.2396

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