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Death diverted, but to what?

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The role of the coreceptor CD28 in thymic clonal deletion has been controversial. New evidence suggests that CD28 deficiency impairs the clonal deletion of self-reactive T cells but also results in their developmental diversion to an anergic lineage that ends up in the gut.

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Figure 1: Outcomes of high-affinity TCR signaling in the thymus.

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Authors and Affiliations

  1. Gretta L. Stritesky and Kristin A. Hogquist are in the Department of Laboratory Medicine & Pathology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.,

    Gretta L Stritesky & Kristin A Hogquist

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  1. Gretta L Stritesky
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  2. Kristin A Hogquist
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Correspondence to Kristin A Hogquist.

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The authors declare no competing financial interests.

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Stritesky, G., Hogquist, K. Death diverted, but to what?. Nat Immunol 13, 528–530 (2012). https://doi.org/10.1038/ni.2311

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