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IgE class switching and cellular memory

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After class switching in naive B cells, memory B cells and plasma cells that produce immunoglobulin E (IgE+ cells) develop through a germinal-center IgE+ intermediate cell without an IgG1 phase. In addition, cellular IgE memory resides in IgE+ memory B cells, and IgG1+ memory B cells are not an important source of IgE memory.

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Figure 1: A model for the generation of IgE+ memory B cells.

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Authors and Affiliations

  1. Mübeccel Akdis and Cezmi A. Akdis are with the Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.,

    Mübeccel Akdis & Cezmi A Akdis

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  1. Mübeccel Akdis
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  2. Cezmi A Akdis
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Correspondence to Cezmi A Akdis.

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The authors declare no competing financial interests.

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Akdis, M., Akdis, C. IgE class switching and cellular memory. Nat Immunol 13, 312–314 (2012). https://doi.org/10.1038/ni.2266

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