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A new therapeutic strategy for malaria: targeting T cell exhaustion

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Boosting immune responses during malaria remains a challenge. Overcoming T cell exhaustion by blocking coinhibitory receptors offers a promising lead.

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Figure 1: T cell exhaustion.

Katie Vicari

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Authors and Affiliations

  1. Gordon J. Freeman is in the Department of Medical Oncology, Department of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.,

    Gordon J Freeman

  2. Arlene H. Sharpe is in the Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.,

    Arlene H Sharpe

Authors
  1. Gordon J Freeman
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  2. Arlene H Sharpe
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Correspondence to Gordon J Freeman.

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Competing interests

G.J.F. and A.H.S. have patents in the PD-1 field and receive patent royalties.

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Freeman, G., Sharpe, A. A new therapeutic strategy for malaria: targeting T cell exhaustion. Nat Immunol 13, 113–115 (2012). https://doi.org/10.1038/ni.2211

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