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Turning transcription on or off with STAT5: when more is less

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The transcription factor STAT5 can activate or repress gene expression depending on whether binding of dimer or tetrameric STAT5 occurs. Tetrameric STAT5 recruits the chromatin modifier Ezh2 to silence gene expression.

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Figure 1: Cytokine-dependent activation of STAT5 results in the translocation of STAT5 homodimers to the nucleus.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, Michael A. Farrar and Lynn M. Heltemes Harris are in the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.,

    Michael A Farrar & Lynn M Heltemes Harris

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  1. Michael A Farrar
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  2. Lynn M Heltemes Harris
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Correspondence to Michael A Farrar.

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The authors declare no competing financial interests.

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Farrar, M., Harris, L. Turning transcription on or off with STAT5: when more is less. Nat Immunol 12, 1139–1140 (2011). https://doi.org/10.1038/ni.2163

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