The kinase LRRK2 is a risk factor for inflammatory bowel disease. New data show that LRRK2 blocks the transport of NFAT to the nucleus and that LRRK2 deficiency results in enhanced susceptibility to experimental colitis in mice.
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Jabri, B., Barreiro, L. Don't move: LRRK2 arrests NFAT in the cytoplasm. Nat Immunol 12, 1029–1030 (2011). https://doi.org/10.1038/ni.2139
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DOI: https://doi.org/10.1038/ni.2139
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