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An unexpected role for MHC class II

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In addition to their classical function in antigen presentation and their lesser known ability to act as signal transducers, major histocompatibility complex class II molecules are now shown to promote Toll-like receptor signaling. This intriguing role requires intracellular association with the kinase Btk and the costimulatory molecule CD40.

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Figure 1: A model for crosstalk between TLRs and MHC class II signaling.

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Authors and Affiliations

  1. Département de Médecine, Ghada S. Hassan and Walid Mourad are with the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Hôpital Saint Luc, Montréal, Canada.,

    Ghada S Hassan & Walid Mourad

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  1. Ghada S Hassan
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  2. Walid Mourad
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Correspondence to Walid Mourad.

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The authors declare no competing financial interests.

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Hassan, G., Mourad, W. An unexpected role for MHC class II. Nat Immunol 12, 375–376 (2011). https://doi.org/10.1038/ni.2023

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