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The genome's best friend

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DNA replication through mononucleotide runs is frequently associated with slippage of DNA polymerase, leading to the insertion or deletion of a small number of base pairs. A new study shows that, in the absence of DOG-1, a putative helicase, long poly(dG/C) runs are associated with deletions that extend into flanking DNA sequences. This mutational signature may be related to the ability of poly(dG) to form secondary structures such as G-quadruplex DNA, and may contribute to the genomic instability of tumor cells.

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Figure 1: Mutations in dog-1 cause a mutator phenotype, which generates deletions near G-rich sequences.
Figure 2: A model for DOG-1 action.

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  1. Department of Biology, Emory University, Atlanta, 30322, Georgia, USA

    Sue Jinks-Robertson

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  1. Sue Jinks-Robertson
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Jinks-Robertson, S. The genome's best friend. Nat Genet 31, 331–332 (2002). https://doi.org/10.1038/ng936

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