Abstract
We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.
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References
Pollack, J.R. et al. Nature Genet. 23, 41–46 (1999).
Anzick, S.L. et al. Science 277, 965–968 (1997).
Collins, C. et al. Proc. Natl Acad. Sci. USA 95, 8703–8708 (1998).
Nonet, G.H. et al. Cancer Res. 61, 1250–1254 (2001).
Wu, G. et al. Cancer Res. 61, 4951–4955 (2001).
Monni, O. et al. Proc. Natl Acad. Sci. USA 98, 5711–5716 (2001).
Jacobs, J.J. et al. Nature Genet. 26, 291–299 (2000).
Blume-Jensen, P. & Hunter, T. Nature 411, 355–365 (2001).
Schwab, M. Semin. Cancer Biol. 9, 319–325 (1999).
Zheng, P., Eastman, J., Vande Pol, S. & Pimplikar, S.W. Proc. Natl Acad. Sci. USA 95, 14745–14750 (1998).
Takekawa, M. et al. EMBO J. 19, 6517–6526 (2000).
Bärlund, M. et al. J. Natl Cancer Inst. 92, 1252–1259 (2000).
Latham, C. et al. Cancer Genet. Cytogenet. 127, 16–23 (2001).
Lanni, J.S., Lowe, S.W., Licitra, E.J., Liu, J.O. & Jacks, T. Proc. Natl Acad. Sci. USA 94, 9679–9683 (1997).
Bulavin, D.V. et al. Nature Genet. 31, 210–215 (2002).
Acknowledgements
We thank Jodi Harris for preparation of the figures.
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Li, J., Yang, Y., Peng, Y. et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet 31, 133–134 (2002). https://doi.org/10.1038/ng888
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DOI: https://doi.org/10.1038/ng888
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