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Small changes in expression affect predisposition to tumorigenesis

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Abstract

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

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Figure 1: Reduced expression of one allele in affected individuals with FAP.
Figure 2: Loss-of-heterozygosity analysis.

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Acknowledgements

This work was supported by grants from the National Institutes of Health.

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Authors and Affiliations

  1. The Howard Hughes Medical Institute, The Oncology Center,

    Hai Yan, Kathy Romans, Francis M. Giardiello, Kenneth W. Kinzler & Bert Vogelstein

  2. The Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, 21231, Maryland, USA

    Hai Yan, Kathy Romans, Francis M. Giardiello, Kenneth W. Kinzler & Bert Vogelstein

  3. Department of Research, Research Group Human Genetics, University Hospital, Basel, 4031, Switzerland

    Zuzana Dobbie

  4. Division of Molecular Medicine and Genetics, University of Michigan Medical School and School of Public Health, Ann Arbor, 48109, Michigan, USA

    Stephen B. Gruber

  5. Department of Medicine and Ireland Cancer Center, Howard Hughes Medical Institute, Case Western Reserve University, University Hospitals of Cleveland and the Research Institute of University Hospitals of Cleveland, Cleveland, 44106, Ohio, USA

    Sanford Markowitz

Authors
  1. Hai Yan
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  2. Zuzana Dobbie
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  3. Stephen B. Gruber
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  4. Sanford Markowitz
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  5. Kathy Romans
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  6. Francis M. Giardiello
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  7. Kenneth W. Kinzler
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  8. Bert Vogelstein
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Correspondence to Bert Vogelstein.

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Yan, H., Dobbie, Z., Gruber, S. et al. Small changes in expression affect predisposition to tumorigenesis. Nat Genet 30, 25–26 (2002). https://doi.org/10.1038/ng799

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  • DOI: https://doi.org/10.1038/ng799

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