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No association of germline alteration of MSR1 with prostate cancer risk

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Abstract

The macrophage scavenger receptor 1 gene (MSR1) was recently identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer. To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. Our results do not support MSR1 as a risk factor for prostate cancer.

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Acknowledgements

We thank D. Johnson for secretarial support. This study was supported by grants from the Public Health Service, US National Institutes of Health.

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Authors and Affiliations

  1. Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, 920 Hilton Building, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota, USA

    Liang Wang, Julie M Cunningham, Scott Hebbring & Stephen N Thibodeau

  2. Department of Health Sciences Research, Harwick Building, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota, USA

    Shannon K McDonnell, Steven J Jacobsen, James R Cerhan, Susan L Slager & Daniel J Schaid

  3. Department of Urology, 7-130 Gonda Building, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota, USA

    Michael L Blute

Authors
  1. Liang Wang
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  2. Shannon K McDonnell
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  3. Julie M Cunningham
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  4. Scott Hebbring
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  5. Steven J Jacobsen
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  6. James R Cerhan
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  7. Susan L Slager
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  8. Michael L Blute
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  9. Daniel J Schaid
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  10. Stephen N Thibodeau
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Corresponding author

Correspondence to Stephen N Thibodeau.

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The authors declare no competing financial interests.

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Wang, L., McDonnell, S., Cunningham, J. et al. No association of germline alteration of MSR1 with prostate cancer risk. Nat Genet 35, 128–129 (2003). https://doi.org/10.1038/ng1239

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  • DOI: https://doi.org/10.1038/ng1239

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