Lipoprotein lipase, the enzyme that hydrolyzes fatty acids from triglycerides carried by circulating lipoproteins, resides on the surface of the capillary endothelium. Analysis of a hypertriglyceridemic mutant mouse has now identified a protein, LMF1, that is critical for the transport of active lipoprotein lipase through the secretory pathway.
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Kim Caesar
References
Jacobson, T.A., Miller, M. & Schaefer, E.J. Clin. Ther. 29, 763–777 (2007).
Suviolahti, E., Lilja, H.E. & Pajukanta, P. Ann. Med. 38, 337–351 (2006).
Péterfy, M. et al. Nat. Genet. 39, 1483–1487 (2007).
Blasiole, D.A., Davis, R.A. & Attie, A.D. Mol. Biosyst. 3, 608–619 (2007).
Boedeker, J.C., Doolittle, M.H. & White, A.L. J. Lipid Res. 42, 1858–1864 (2001).
Ben-Zeev, O., Mao, H.Z. & Doolittle, M.H. J. Biol. Chem. 277, 10727–10738 (2002).
Beigneux, A.P. et al. Cell Metab. 5, 279–291 (2007).
Sukonina, V., Lookene, A., Olivecrona, T. & Olivecrona, G. Proc. Natl. Acad. Sci. USA 103, 17450–17455 (2006).
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Attie, A. High-maintenance proteins and hypertriglyceridemia. Nat Genet 39, 1424–1425 (2007). https://doi.org/10.1038/ng1207-1424
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DOI: https://doi.org/10.1038/ng1207-1424
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