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Gaining insight into PTPN22 and autoimmunity

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The protein tyrosine phosphatase PTPN22 (also called LYP) is the leading example of a genetic variant that confers risk of developing diverse human autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, autoimmune thyroid disease and systemic lupus. A new study now shows that the PTPN22 risk-associated variant, Trp620, results in a gain of PTPN22 phosphatase activity in T cells, opening up new avenues for exploring disease mechanisms.

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Figure 1: The PTPN22 R620W substitution results in a gain of enzymatic function that is predicted to increase the threshold for TCR signaling.

Katie Ris

References

  1. Bottini, N. et al. Nat. Genet. 36, 337–338 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Begovich, A.B. et al. Am. J. Hum. Genet. 75, 330–337 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kyogoku, C. et al. Am. J. Hum. Genet. 75, 504–507 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Velaga, M.R. et al. J. Clin. Endocrinol. Metab. 89, 5862–5865 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. Criswell, L.A. et al. Am. J. Hum. Genet. 76, 561–571 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Begovich, A.B. et al. Am. J. Hum. Genet. 76, 184–187 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. van Oene, M. et al. Arthritis Rheum. 52, 1993–1998 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Hasegawa, K. et al. Science 303, 685–389 (2004).

    Article  CAS  PubMed  Google Scholar 

  9. Vang, T. et al. Nat. Genet. 37, 1317–1319 (2005).

    Article  CAS  PubMed  Google Scholar 

  10. Carlton, V.E. et al. Am. J. Hum. Genet. 77, 567–581 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Liston, A., Lesage, S., Gray, D.H., Boyd, R.L. & Goodnow, C.C. Immunol. Rev. 204, 87–101 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. Sakaguchi, N. et al. Nature 426, 454–460 (2003).

    Article  CAS  PubMed  Google Scholar 

  13. Sakaguchi, S. Nat. Immunol. 6, 345–352 (2005).

    Article  CAS  PubMed  Google Scholar 

  14. Atabani, S.F. et al. Eur. J. Immunol. 35, 2157–2162 (2005).

    Article  CAS  PubMed  Google Scholar 

  15. Siminovitch, K.A. Nat. Genet. 36, 1248–1249 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

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  1. the Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, 11030, New York, USA

    Peter K Gregersen

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  1. Peter K Gregersen
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Gregersen, P. Gaining insight into PTPN22 and autoimmunity. Nat Genet 37, 1300–1302 (2005). https://doi.org/10.1038/ng1205-1300

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