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Unfolding heterochromatin for replication

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For DNA replication to proceed through heterochromatin, the replication machinery must negotiate the highly condensed chromatin. A new study shows that an ACF1–ISWI chromatin remodeling complex is required for the replication of pericentromeric heterochromatin. This complex may act to unravel chromatin structure in these regions of the genome, thereby permiting movement of the replication fork.

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Figure 1: Electron micrographs of heterochromatin in nuclei from human placenta
Figure 2: A model of replication of heterochromatin.

Bob Crimi

References

  1. Dillon, N. & Festenstein, R. Trends Genet. 18, 252–258 (2002).

    Article  CAS  Google Scholar 

  2. Collins, N., Poot, R., Kukimoto, I., Garcia-Jimenez, C. & Varga-Weisz, P. Nature Genet. 32, 627–632 (2002).

    Article  CAS  Google Scholar 

  3. Richards, E.J. & Elgin, S.C. Cell 108, 489–500 (2002).

    Article  CAS  Google Scholar 

  4. Bannister, A.J. et al. Nature 410, 120–124 (2001).

    Article  CAS  Google Scholar 

  5. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. Nature 410, 116–120 (2001).

    Article  CAS  Google Scholar 

  6. Nakayama, J., Rice, J.C., Strahl, B.D., Allis, C.D. & Grewal, S.I. Science 292, 110–113 (2001).

    Article  CAS  Google Scholar 

  7. Jones, P.A. & Takai, D. Science 293, 1068–1070 (2001).

    Article  CAS  Google Scholar 

  8. Jones, P.L. et al. Nature Genet. 19, 187–191 (1998).

    Article  CAS  Google Scholar 

  9. Ng, H.H. et al. Nature Genet. 23, 58–61 (1999).

    Article  CAS  Google Scholar 

  10. Tsukiyama, T. Nature Rev. Mol. Cell Biol. 3, 422–429 (2002).

    Article  CAS  Google Scholar 

  11. Langst, G. & Becker, P.B. J. Cell Sci. 114, 2561–2568 (2001).

    CAS  Google Scholar 

  12. Alexiadis, V., Varga-Weisz, P.D., Bonte, E., Becker, P.B. & Gruss, C. EMBO J. 17, 3428–3438 (1998).

    Article  CAS  Google Scholar 

  13. Tate, P., Lee, M., Tweedie, S., Skarnes, W.C. & Bickmore, W.A. J. Cell Sci. 111 (Pt 17), 2575–2585 (1998).

    CAS  Google Scholar 

  14. Fuss, J. & Linn, S. J. Biol. Chem. 277, 8658–8666 (2002).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01655, Massachusetts, USA

    Ivana L. de la Serna & Anthony N. Imbalzano

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  1. Ivana L. de la Serna
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  2. Anthony N. Imbalzano
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Correspondence to Anthony N. Imbalzano.

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de la Serna, I., Imbalzano, A. Unfolding heterochromatin for replication. Nat Genet 32, 560–562 (2002). https://doi.org/10.1038/ng1202-560

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