Two new studies explore the genetic mechanisms connecting aging and tumor growth in Caenorhabditis elegans. This work should provide a basis to consider ways to prevent and treat age-dependent cancers.
References
Pinkston, J.M., Garigan, D., Hansen, M. & Kenyon, C. Science 313, 971–975 (2006).
Pinkston-Gosse, J.M. & Kenyon, C. Nat. Genet. 39, 1403–1409 (2007).
Kenyon, C. Cell 120, 449–460 (2005).
Francis, R., Maine, E. & Schedl, T. Genetics 139, 607–630 (1995).
Paik, J.H. et al. Cell 128, 309–323 (2007).
Hu, M.C. et al. Cell 117, 225–237 (2004).
Di Cristofano, A., Pesce, B., Cordon-Cardo, C. & Pandolfi, P.P. Nat. Genet. 19, 348–355 (1998).
Nemoto, S., Fergussin, M.M. & Finkel, T. Science 306, 2105–2108 (2004).
You, H. et al. Proc. Natl. Acad. Sci. 101, 14057–14062 (2004).
Chen, Z. et al. Nature 436, 725–730 (2005).
Levine, B. Nature 446, 745–747 (2007).
Campisi, J. Cell 120, 513–522 (2005).
Matheu, A. et al. Nature 448, 375–379 (2007).
Finkel, T., Serrano, M. & Blasco, M.A. Nature 448, 767–774 (2007).
Murphy, C. et al. Nature 424, 277–283 (2003).
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Brunet, A. Aging and cancer: killing two birds with one worm. Nat Genet 39, 1306–1307 (2007). https://doi.org/10.1038/ng1107-1306
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DOI: https://doi.org/10.1038/ng1107-1306
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