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Buffering mitochondrial DNA variation

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Reactive oxygen species (ROS) are traditionally viewed as the toxic by-product of cellular respiration. A new study suggests a homeostatic role for ROS in maintaining stable respiratory phenotypes across genetic variants of the mitochondrial genome.

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Figure 1: The generation and consequences of ROS in mitochondria.

Kim Caesar

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Authors and Affiliations

  1. Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, 02114, Massachusetts, USA

    Joshua M Baughman & Vamsi K Mootha

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  1. Joshua M Baughman
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  2. Vamsi K Mootha
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Baughman, J., Mootha, V. Buffering mitochondrial DNA variation. Nat Genet 38, 1232–1233 (2006). https://doi.org/10.1038/ng1106-1232

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