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A keaper and a striker maintain epidermal homeostasis

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The actin-associated kelch-domain protein Keap1 acts upstream of the transcription factor Nrf2. Upon stress, Keap1 releases Nrf2 to activate the transcription of target genes. A new study now shows that these targets include keratins and cornified envelope proteins, possibly explaining why certain keratin mutations predispose to chemical injury. The Keap1-Nrf2 partnership offers a mechanistic explanation for the response of tissues to mechanical and chemical injury.

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Figure 1: Keap1-mediated transcription.

Katie Ris

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  1. Abteilung fuer Zellbiochemie, the Institut fuer Physiologische Chemie, and LIMES, Rheinische Friedrich-Wilhelms-Universitaet, Nussallee 11, Bonn, D-53115, Germany

    Thomas M Magin

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  1. Thomas M Magin
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Magin, T. A keaper and a striker maintain epidermal homeostasis. Nat Genet 35, 202–204 (2003). https://doi.org/10.1038/ng1103-202

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